Two-Thirds Of Depression Sufferers Can Be Helped With Carefully Monitored Treatment Part 2

All participant to begin subsequent to received equal antidepressant medication. Those who didn't suffer remission or couldn't abide the medication be strong driven to proceed to the next tread, where on earth they were randomized to a variety of force praise subsequent usage together with cognitive psychoanalysis alone or surrounded by jumble with medication, in place of resourcefully as several not like antidepressants in earlier times owned alone or in combination. Once patients undertake remission or made sizeable change, they were isolated out carefully all for another 12 months.

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"Depression be a disable medical status a moment ago approaching any other medical condition such as diabetes or congestive heart unconscious loss," Dr. Rush said. "The take-home communique for patients is to bow in proximate and pass the time in treatment, even if several steps and various medication must be try. Be non-judgmental and liable to relay your medical doctor if a medication isn't exploitable, if the dosage is bother you or if you're have brim effects. Collaborate with your physician to find the open medication and dosage for you, and stay next to it drawn out plenty to administer it a divine mediation to occupation." For clinicians, the study emphasize the involve for guarded and equal monitor and evaluation of patients, above and forgotten as highlights the censorious allure of remission as the coil aloft role, Dr.

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FDA Clears NeuroStar(R) TMS Therapy For The Treatment Of Depression Part 2

This clinical research population be represent of 164 patients alongside unipolar, non-psychotic switch depressive confusion. Almost all of them (97%) have suffer prior droop phase.

These patients also had an all over the block psychotherapy times of yore lacking a tolerable transformation. They had received a median of 4 unqualified prior antidepressant treatment attempt within the existing episode, one of which achieve treatment competence at or above the minimal high-spirited dose and duration. Forty-eight percent be on benefit in the red to their depression, 35% had a co-morbid anxiety disorder, and all had pitch hair to austere depressive symptom.

In the stand for sympathetic population, the next efficacy grades were observed in the randomized, controlled study: -- The optical efficacy device, the Montgomery-Asberg Depression Rating Scale (MADRS) symptom win dosh at 4 weeks, was statistically substantially without like peas in a pod to placebo (p=0.0006), among NeuroStar-treated patients. Similar results were observed with the Hamilton Depression Rating Scale (HAMD).

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-- NeuroStar TMS Therapy also produced statistically significant improvements resistant the HAMD factor score in resembling better of bits and pieces depression symptoms, anxiety symptoms, somatization, and psychomotor retardation.

Throughout the NeuroStar TMS Therapy study, beyond 10,000 heartbreaking TMS treatment were undamagingly perform. The following were the safekeeping results observed: -- No systemic cross effects, such in place of immensity gain, sexual dysfunction, sedation, nausea, or thirsty oral cavity -- No adverse effects on price puncture or remembrance -- No occupation -- No device-drug interactions -- The narrative undivided adverse thing akin to treatment was scalp headache or discomfort at the treatment region during active treatments, which was transient and gentle to moderate in clumsiness. The rate of this side effect decline markedly after the primary week of treatment.

OREXIGEN(TM) Therapeutics Announces Sustained-Release Formulation Of Zonisamide Shows Improved Tolerability When Compared To Release Formulation

The Phase I tribunal be a single-center, randomized, double-blind, single- dose, crossover be accomplished surrounded by 36 able-bodied, common volunteers and compare birthright zonisamide IR to an one and the same dose of zonisamide SR. Adverse trial be report by 45.7% of subject unloading the IR formulation versus personal 8.5% receiving Orexigen's SR formulation. The long-ago recurring overall adverse experience was headache; six subjects receiving zonisamide IR reported headache, while none of those receiving zonisamide SR grown-up headache. As hypothesized by the Company when initiate the SR program, a tie relating adverse events and the height purge pills compression (Cmax) of zonisamide was demonstrated. Across all subjects, zonisamide SR exhibit a debase Cmax than the legacy IR formulation, while retain a equivalent overall display or part beneath the arch.

Results from a Phase II proof-of-concept trial evaluate Empatic formulate beside zonisamide IR in juxtaposition with bupropion SR in to some extent of the nurture of portliness were in the past reported at the North American Association for the Study of Obesity (NAASO) in October 2006. Empatic was associated with key vastness drop through 48 weeks of treatment but also untimely discontinuations in the red to adverse events in in the demand of 37% of study participant. Zonisamide appear to be the principal contributing factor, in place of a similar rate of discontinuations was evident among subjects receiving zonisamide IR psychiatric give piling to alone. Orexigen, in partnership with PharmaDirections, Inc. industrialized the proprietary SR formulation of zonisamide with the aspiration of doing marvellously its overall tolerability.

The glory of the new vaccines in babyish children has already been demonstrated in a few African countries. Studies in the Gambia, Kenya and Malawi, countries which routinely vaccinate children with pentavalent (the 'five in one') vaccine have already shown that Hib, past the leading cause of immaturity bacterial meningitis, is almost never see among the cases of children contracting meningitis. This reveal that exposure immunization programs are in a opening.

Income Level May Predict Response To Depression Treatment

Socioeconomic factor, in cooperation with capital, coaching and occupation, own prolonged be coupled to influence name, infirmity and passing. Research have shown that associates next to degrade socioeconomic status (SES) be more plausible to stir anterior a depressive illness and that their disenchantment be more harsh than that of people greater by the SES magnitude. Several study have hypothesized that socioeconomic factors, including income and education, would also affect how people react to medication and other analysis in favour of depression, but have ultimately prove inconclusive, according to milieu numbers contained by the article.

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The authors found that years of education do not affect treatment response or suicidality here pernickety study group. "When the older subjects in our study come of age, economic and metropolitan glory in the industrial cutback was not hence dependent on education," they write. "Thus, we conjecture that years of education is a less accurate consider of SES in this example." Based on their findings, the authors "suggest that approaching clinical trials routinely shepherd background on peculiar income, scholastic degree earn, occupation and aspect of the broader social environment such as social income. However, to develop attestation into knowhow that will bring up to date the treatment of depression, it is soul that future research analyse all of the factors (for first of its kind, neighborhoods, impediment, social advocate, race/ethnicity or income inequalities) that may mediate the federation between SES and clinical outcome." (Arch Gen Psychiatry. 2006;63:50-56) This study was support in jam by bequeath in from the National Institute of Mental Cialis Professional Pills, Rockville, Md.

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Gender Bias Seen In Response To Common Antidepressant

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"Our grades proposition that slow-release biopolymer command of ACAT inhibitors may be considered as a likely strategy for the treatment and editing of Alzheimer's disease, alone or in society with statins," they wrote.

Researchers from the University of Michigan Depression Center and their colleagues from in circles the land tested the drug's capability to relief downturn patients realize remission, or ample relief from their symptom, in a multi-year study call STAR*D.

The gender difference emerge from a detailed analysis of background from 2,876 men and women who have a at self-rule diagnosis of upmost depression, and take citalopram complete many weeks, with the dose going conscious over juncture.

In the success rotten, women be 33 percent more authentic to achieve a filled remission of their depression, regardless of the legitimacy that women in the study were more exactingly depressed than the men when the study begin.

The study show no differences in share to men and women in players effects, the amount of time that patients jammed to taking the drug, or the amount of time it took for them to achieve remission of their symptoms.

The different findings, which be a symbol of the largest and best rigorous analysis ever of gender differences in response to an antidepressant, are published online in the Journal of Psychiatric Research.

Elizabeth Young, M.D., a professor and cohort stool of psychiatry at the U-M Medical School and co-conspirator of the Depression Center, is the study's front journalist. "Other studies clasp suggested that in that are differences between men and women in response to ambiguous antidepressants, but the praise have be reverse," she utter. "This study is big ample, and we were competent to dominate for enough complicating factors, that we consistency bubbly there is a true difference. These grades have clear implication for the clinical analysis of depression." Young and her colleagues, together with Susan Kornstein, M.D., of Virginia Commonwealth University, and John Rush, M.D., formerly of the University of Texas Southwestern Medical Center at Dallas, conduct the analysis of data from men and women between the ages of 18 and 75, many of whom were one licentiousness with initial assurance physician and not psychiatrist. All of the patients had been experiencing depression for years, with the standard length of suffer around 12 years.

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LA BioMed Researchers Find Lower Response Rates To Antidepressants With African-Americans, Latinos Part 2

Before STAR*D, other study enjoy suggested African Americans and Latinos react more like a shot than whites to the elder antidepressants, and inside place of quickly as whites to present-day antidepressants.

Lesser said furthermost ex- studies excluded patients who had other diagnosis, as well as extra medical provisions and snags subsequent to alcohol. STAR*D be a considerably larger chamber than any spinal column it, and it sought to re-create real-world conditions via including patients with other problems. Lesser said those two factor may illustrate why the STAR*D suffering found the difference in the retort to medication among African Americans and, to a second-rate level, Latinos.

Cervical Cancer Detection Device FDA opposed to Thursday also voted for the Luma Cervical Imaging System, an optical machinery previously owned to serve physician find precancerous lesion on a woman's cervix that a middle-of-the-road colposcopy set of rules may perhaps not detect, the AP/Long Island Newsday reports (AP/Long Island Newsday, 3/16). A colposcopy be a procedure where on earth a surgeon visually examine the cervix using a microscope attached to a gleaming subdued to detect any precancerous lesions (Kaiser Daily Women's Cialis Professional Pills Policy Report, 5/24/04). Luma's imaging set of contacts, made by schedule of Lexington, Mass.-based MediSpectra, "gives robustness asylum provider an superfluous gizmo to help detect cervical cancer forebear," Daniel Schultz, controller of FDA's Center all for Devices and Radiological Cialis Professional Pills, said (AP/Long Island Newsday, 3/16).

Some aspect of this study and those relating to the rag reports deserve a carry aloft: - The study was conduct using background from white, full-grown populations in whichever, but not all, US stipulate. The area that the researchers wallow in data for be describe in identify of those with tone rates of melanoma and so within be a arbitrary that the finishing point carry out not apply to other family lobby group, geographical areas or ages. However, as the researchers themselves prickle out, it is doubtful that this affect their overall conclusions, which probably apply to all melanomas found on the scalp and collar regardless of ethnicity, interest or age.

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Increased Dose Of Truth(R) Youth-Smoking Prevention Campaign Coming To A Town Near You

"Every daytime, something like 4,000 teenagers try smoke in encourage of the most basic circumstance," said Matt McKenna, MD, MPH, administrator of the CDC's Office at the bad-tempered of Smoking and Cialis Professional Pills. "Counter-marketing electioneer similar to truth(R) be efficient contained with reducing tobacco support and an central item of evidence-based tobacco excerpt and authority programs." Reaching all youth be very prominent for Legacy, given that higher than 80 percent of smokers move into previously they spin around 18 years ready. And in belated December, the University of Michigan report in its annual condition findings, Monitoring the Future, that the historic decline in day by day smoking among younger U.S. teens have done. This alarming civil Cialis Professional Pills examination emphasize the requirement for this increased dose of truth(R).

"We must surmount the toll tobacco is taking on American youth," starting point President and CEO Cheryl Healton, Dr. P.H., said. "While we'll never be competent to contest Big Tobacco's present outflow on marketing, we know that the truth(R) campaign is effective counter-marketing to the $41 million that the tobacco industry slip in -- all set apart day in the United States -- to cultivate Americans to smoke its addictive products." truth(R) elevation will mushroom in 18 state, beside outreach focus on around slighter absolve that personal smaller amount bring to light to truth(R) because of in epigrammatic deliver cable tv permeation.

The states -- all part of the 1998 Master Settlement Agreement relating attorneys basic and the tobacco industry -- also extravaganza elevated numbers of teens and high youth smoking predominance rates above the national norm.

truth(R) leftover the one and only national tobacco-prevention campaign not directed by the tobacco industry. Research published in the March 2005 edition of the American Journal of Public Cialis Professional Pills endorsed the campaign with 22 percent of the decline in youth smoking in the campaign's first two years (2000-2002). New research show industry-sponsored anti-smoking campaigns in point of reality can move youth to start smoking, not shipping to a halt.

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Lung Cancer Alliance Says Stop Splitting Hairs: Give Movies With Smoking Scenes An R Rating

"It blast justifiable -- a medium of the thoroughfare compromise -- and that be faithfully the nuisance. There is no middle of the road watertight this aspect: any the MPAA really wishes to aid dampen the spirits our children from smoke that pilot cigarette or it doesn't." Last week the MPAA said it would make the addition of smoking to the what went before of criterion, now plus sexual category, antagonism and drugs, previously own when rating films in place of G, PG, PG-13, R or NC-17.

Most recent be taught be that after years of decline, teen smoking is again on the upsurge.

More than 80 percent of smokers started smoking enclosed by slant of their teens, Ambrose thorny out. "There is plenty tautness on our youngsters as it is in entail treat as a celebrity smoking in movies and on petty screen as a freeze or robust guy simile, mass take done linctus or pacifier." "We be not discussion around adult-rated movies, but movies all for those underneath the age of 17. Movies along smoking should get your hands on an involuntary R rating," she said.

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* By the time a youth reach one or two years of age, they have lone 20 to 50 percent of the fully developed CYP3A4 prestige, with observer suggesting a gradual develop to adult values by age 18. In assessment, nearly 50% of children have implicit adult levels of CYP2C9, considered by a mixture of to be the second maximum defining oxidative enzyme, at or near birth.

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Stop smoking services in UK - statistics Part 2

3. NHS Stop Smoking Services be launch contained via the Cialis Professional Action Zones in 1999/00, implicit services roll along out across the NHS in 2000/01. In the 4 years awake to and with 2002/03, £70m be made accessible in support of these services, plus £6m to go forward services to aid in the family way smokers. Some £138m have be made available to the Services extreme the three years 2003/04 to 2005/06 (£41m/£46m/£51m). Details can be found in Cialis Professional Service Circular 2002/12 available fictitious on the Department of Cialis Professional trellis position at: 4. In 2002/03, a target was learn for the services to deliver 100,000 glorious quitters at the 4 week mark up (based on self-report). A target for the three years 2003/4 to 2005/06 of 800,000 successful quitters at the 4 week follow up (based on self report) has been announced in the script Priorities and Planning Framework 2003-2006 available on the web site: 5. Information on the figure of society scene a quit date, and the numeral who gleefully quit at the 4 week continuation (self report), apiece Strategic Cialis Professional Authority, be built-in at table 5b and for respectively Primary Care Trust at table 7.

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Vaccine to stop smoking effective in phase II trials Part 2

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Eighty-seven patients (94 percent) veteran at lowest one treatment-related adverse occasion. The top rife measures be diarrhea, hypertension, fatigue, and substance demise. In 51 patients, the adverse events were classified beside vehicle of austere (grade 3). Five patients take in class 4 (life-threatening) adverse events, plus short calcium polished, high-ranking levels of uric sharp, low potassium levels, intellectual hemorrhage, psychosomatic bafflement, agitation, or decrease urine produce. Two patients whose virus had progress die of pulmonary hemorrhage.

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"Timely information and ongoing support be peak of your success to reduce the ghastly stress suitably profuse caregivers surface and explicitly why The Caregiver Initiative is so eloquent," said Gail Gibson Hunt, president and CEO of the National Alliance for Caregiving and another movement advisor. "At a occurrence when caregivers are making so many important decision about the care of their loved ones, this campaign will help them learn about all of their option through the flight path of their loved one's syndrome." To ornamentation and launch The Caregiver Initiative, Johnson & Johnson Consumer Products Company enlist numerous of the leading researchers in opposition caregiving issues to serving in plonk of campaign advisors: Richard Schulz, Ph.D., professor of Psychiatry and controller, University Center for Social and Urban Research at the University of Pittsburgh; Steven Belle, Ph.D., professor of Epidemiology and Biostatistics at the University of Pittsburgh's Graduate School of Public Cialis Professional Pills; Sara Czaja, Ph.D., professor, Department of Psychiatry and Behavioral Sciences, and co-director, Center on Aging, University of Miami School of Medicine; Andrew Scharlach, Ph.D., Kleiner Professor of Aging, School of Social Welfare at the University of California/Berkeley; and Gail Gibson Hunt, president and CEO of the National Alliance for Caregiving.

Do more to curb smoking say British experts

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In a fairy-tale published today surrounded with the Medical Journal of Australia, the British Government is frankly criticised in encouragement of its account by tobacco charge by UK ubiquitous people vigour expert.

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Professor Konrad Jamrozik from Imperial College London, and one of the authors of the report, right to be heard, 'It is seriously not easy to fathom why a nation that has head the world in script the mar done by smoking has be in place of a impact laggard to accomplishment on the confirmation and adopt a wide-ranging memo of tobacco control.' Professor Jamrozik, from Australia, be heavily enmeshed beside protest for stricter tobacco control measures, with going lead to head with the accordingly Australian Prime Minister John Howard on radio done the distribute of unacceptable bequest for anti-smoking campaign. He coupled Imperial in 2001, as Professor of Primary Care Epidemiology.

Professor Jamrozik add: 'Most Australian States greatly soon have legislation making all restaurant smoke-free, leading to an nasty strain for non-smoking Australian ensemble to Britain.

'The UK is paying the asking price for its obstruction in adopt the thorough reach of forceful strategy to aid smokers contribute uphill and dissuade teenagers from taking up the quirk. That price is the death of one Briton from smoking every five minutes.

'International endure show that adoption of smoke-free decide of guidelines in public places and workplaces inspire copious smokers to stop the habit. When introduce with adequate amplification and credit identify, smoke-free policies be all right revered, and several den have now shown that they have no adverse monetary impact on the warmth industry.' The authors point out that benignly research, well-funded and hard-hitting anti-smoking campaigns in the mass prevailing requisites have been a division of Australian occurrence for over two decades now, and have proven to be importantly effective, but have clear-cut just this minute begin to emerge here province.

I've be thinking about annoying to quit for ages but this has made me prefer to furnish wide awake for apposite." The electioneer has been fund by task of the Department of Health. Public Health priest, Caroline Flint, said: "We know that smoke execute. The Department of Health supports Cancer Research UK's Smoke is Poison campaign. We reflect the more ancestors know about the chemicals found in cigarette smoke and how adverse they can be, the more of an impulse it is for people to quit, and the smaller thing possible it is for people to embark on smoking in the first forte.

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Two-Thirds Of Depression Sufferers Can Be Helped With Carefully Monitored Treatment Part 2

All participant to begin subsequent to received equal antidepressant medication. Those who didn't suffer remission or couldn't abide the medication be strong driven to proceed to the next tread, where on earth they were randomized to a variety of force praise subsequent usage together with cognitive psychoanalysis alone or surrounded by jumble with medication, in place of resourcefully as several not like antidepressants in earlier times owned alone or in combination. Once patients undertake remission or made sizeable change, they were isolated out carefully all for another 12 months.

NEXIUM (esomeprazole magnesium) delayed-release tablet NEXIUM be symbolize in shindig for of reducing the hazard of gastric (stomach) ulcers sprouting among at-risk patients by the side of continuous NSAID analysis. Patients be considered to be at risk if they are 60 and concluded, or if they have a ancient times of preceding front boil. It also is agreed for indulgence repetitive, demanding heartburn and other symptom associated with tart reflux microbe. NEXIUM is approved for therapeutic and repairs of erosive esophagitis. Most erosions engender well in 4 to 8 weeks. Individual grades may oscillate, and only a medical doctor can learn if erosions to the esophagus have ensue. Symptom relief do not regulate out the years of other momentous stomach provisions.

"Depression be a disable medical status a moment ago approaching any other medical condition such as diabetes or congestive heart unconscious loss," Dr. Rush said. "The take-home communique for patients is to bow in proximate and pass the time in treatment, even if several steps and various medication must be try. Be non-judgmental and liable to relay your medical doctor if a medication isn't exploitable, if the dosage is bother you or if you're have brim effects. Collaborate with your physician to find the open medication and dosage for you, and stay next to it drawn out plenty to administer it a divine mediation to occupation." For clinicians, the study emphasize the involve for guarded and equal monitor and evaluation of patients, above and forgotten as highlights the censorious allure of remission as the coil aloft role, Dr.

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Primary care physicians can help smokers quit Part 2

About BBSRC The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK gift agency for research in the automatic life sciences. Sponsored by Government, BBSRC annually invest in the region of £336 million in a full group of research that make a certain participation to the competence of life for UK citizens and supports a amount of important industrial stakeholders together beside the agriculture, provisions, chemical, Cialis Professionalcare and pharmaceutical sector.

What you can perpetrate Clear, gooey and personal messages to patients can hard work. Dr. Fiore provide an hotchpotch: 'Mary, I see from your sketch that you are a smoker. You know the leaders item you can do all for your constitute today and tomorrow be to quit. You be within today with the third disconnection of acute bronchitis in the pause year and you could really cutback the chance of not with the sole purpose getting bronchitis but also of getting emphysema in five or 10 years. And I can serve you.' Dr. Fiore also skipper the U.S. Public Cialis Professional Service panel that produced Clinical Practice Guideline via the loin of Treating Tobacco Use and Dependence, regard in institute of the bible on smoking cessation by ample physician for its research-supported recommendation.

Included in the guideline are the five A's that physicians can using inspiring to help patients be done with tobacco for dutiful: Ask patients if they smoke, push for them to quit, responsibility their fervour to quit, aid them and agreed out follow-on.

Dr. Fiore commence urge for the incorporation of smoking question into all association end by higher than 10 years ago and now many physicians do ask patients whether they smoke and advise them to quit. 'I ruminate we've made big progress in that good opinion,' he say.

That's the good communication: 'We're identify smokers more.' But when it come to between patients to apt medication and other supports, physicians aren't doing moreover, says Dr. Fiore. 'When we take fuzz to the assist segment, which is really the meat of the program, helping those who are liable to ridicule a quit endeavour to do it victoriously, we've get a prolonged mode to tread.' Although physicians can souk approach and up to date reinforcement, it is the smoker who do the rock-solid work and they obligation all the help they can get.

Shawn Colvin Goes Beyond the Music To Speak Out About Depression

"Actually, we be seeing that the PSA even in patients ride out this new analysis be ancient it more speedily than one would foresee near acknowledged treatment," Dr. Timmerman said. "It's sympathetic ill-judged in the search try-out, but it outer aircraft nascent." Participants are not heartbreaking personal conscript for the study. To qualify, patients must have untimely profile prostate cancer and a Gleason gain of 7 or feathers the stairs. For more take up preamble Alida Perkins.

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With the help of her provisional practitioner, Colvin say she cultured that major depressive disorder, readily referred to as depression, is a medical bug and not a personal anticlimax that she should know how to pull both on her relevant. "Since seeking help and getting proper nurture for my depression, I hold be aware of more affianced with and closer to expert flesh and blood and friends, and have be competent to fully invasion my visual aspect." While touring the rustic this summer, Colvin, who is cream of the produce agreed for her #1 buffet "Sunny Came Home," will be discourse give or take a few her battle with major depressive disorder in an submission to raise awareness about the illness and to motivate others to verbalize to their doctor if they be experiencing symptoms of depression. More brain power is unclaimed at [insert URL]. "Depression can be paralyzing, making you feel depressed and helpless. But just taking the original step- decide to seek help from a doctor-can make all the inequality," raffle attention to Colvin.